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It has been suggested for some time that PM2·5 (the smallest type of particulates found in emissions which go unfiltered into the lungs) are associated with increased risk of diabetes; however, nobody really knew how big the effect was.
To really dig down on what was happening, last year scientists took a group of 1,729,108 US veterans and followed them to see what happened over an 8.5-year period, taking note of the all the fine details, where they live and PM2.5 levels.
Diabetes was recorded by using the International Classification of Diseases-9 code, diabetes medication prescription or abnormal blood glucose level tests.
A 10 μg/m3 (micrograms per cubic metre) increase in PM2·5 was associated with increased risk of diabetes and exposure to PM2·5 was associated with increased risk of death. An integrated exposure response function showed that the risk of diabetes increased substantially above 2·4 μg/m3, and then exhibited a more moderate increase at concentrations above 10 μg/m3.
Globally, ambient PM2·5 contributed to about 3.2million incident cases of diabetes, about 8.2million disability adjusted life year (DALYs) caused by diabetes, and 206,105 deaths from diabetes attributable to PM2·5 exposure, especially in low-income and lower-to-middle-income countries.
Importantly, the study shows that substantial risk exists at concentrations well below those outlined in the air quality standards of WHO and national and international regulatory agencies, meaning targets need to tighten even further.
The biological mechanism underpinning the association is based on the premise that pollutants enter the bloodstream where they might interact with tissue components to produce pathological effects. This mechanism is now supported by evidence both in experimental models and humans that inhaled nanoparticles, which when sufficiently small can enter the bloodstream and interact with distant organs—including liver tissue—and exhibit affinity to accumulate at sites of blood vessel (vascular) inflammation.
Both research studies and human evidence suggest that exposure to ambient air pollutants can lead to clinically significant disturbances in oxidative stress, inflammation, cell division and broad metabolic derangements in glucose and insulin homoeostasis. This includes glucose intolerance, decreased insulin sensitivity and impaired secretion, and increased blood lipid concentrations, thus providing biological mechanistic plausibility to the association of PM2·5 exposure and the risk of diabetes.
The global burden of diabetes attributable to PM2·5 air pollution is significant. Reduction in exposure will yield substantial health benefits, but protecting the body from not only breathing particles in, but also providing antioxidant and anti-inflammatory agents must also become a focus until things that contribute to emissions, such as diesel fuels, are faded out.
Altruvita’s Air Pollution Formula is designed to provide natural support in a polluted world, click here to learn more about this food supplement.
Living or working in the UK’s most polluted cities and towns increases the risk of an early death by the equivalent of smoking three cigarettes a week, the British Heart Foundation (BHF) has warned today.
The BHF has called for air pollution to be declared “a public health emergency” following the starling results of a research project funded by the charity. The study in question found that breathing in the particulate matter found in polluted air is a serious risk factor for diseases effecting the circulatory system.
Around 11,000 coronary heart disease and stroke deaths each year in the UK are caused by particulate matter air pollution. It can also worsen existing health problems such as respiratory illnesses, but in truth it effects every part of our body.
It’s the PM2.5 – the smallest of the particulate matter found in vehicle emissions – that are of most concern, as these cannot be filtered out of the air we breathe by our nostrils or the tube going down into the lungs.
The BHF analysis shows that the Chelsea, Newham, Westminster, Kensington and Islington areas of London are worst hit by air pollution – the equivalent to smoking more than 150 cigarettes a year on average. Those in Waltham Forest, Hackney, Tower Hamlets, Barking and Dagenham, Lambeth and Southwark in London are also badly affected, as are people in Slough, Dartford, Gravesham, Thurrock, Portsmouth, Medway and Luton,
The results of studies such as these have led to an increase in demands that the next government should urgently introduce the much tougher World Health Organisation (WHO) air pollution limits in place of EU limits. the current EU limits – which the UK comfortably meets – for fine particulate matter (PM2.5) are 25 micrograms per metre cubed as an annual average. The WHO limits are much tougher – at 10 micrograms per metre cubed as an annual average. The potential health benefits of lowering these levels would allow everyone to live healthier lives for longer.
it’s not all doom and gloom – we’ve recently written about how dietary components can help play a role in combatting the effects of air pollution, which you can read about here. Altruvita’s medical and nutritionist team has also developed Air Pollution Formula, the very first food supplement of its kind and designed to provide natural support in a polluted world.
There are many ways you can try to limit your exposure to both indoor and outdoor air pollution, and to help you out we’ve gathered them together in our insightful Air Pollution Survival Guide. Download your FREE copy here.
Tried and tested.
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