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Crohn’s disease and Ulcerative Colitis are the two most common forms of Inflammatory Bowel Disease (IBD), and together they affect more than 300,000 people in the UK. IBDs can trigger a wide range of symptoms including pain, cramps, weight loss, extreme tiredness, diarrhoea and swelling of the stomach. 

Due to the high prevalence of nutrient deficiencies in patients with IBD, routine monitoring of nutrient status and supplementation are recommended. Not only are deficiencies a wider problem, but the resulting inflammation causes pain and intolerance to food during flare ups when the diseases are active.

Our Xanthohumol+ hop extract is full of wonderful things, including a small amount of phytoestrogens and a much higher concentration (10%) of xanthohumol. Xanthohumol is a prenylated flavonoid unique to hops.

A team in Portland, Oregon, who have been running multiple studies investigating the health benefits of xanthohumol hop extracts, have released their latest preliminary study, this time in IBD. The formula contained xanthohumol and curcumin, which is well studied for its anti-inflammatory effects* in IBD. The formula also contained a mixture of micronutrients (including methylated forms of folate and vitamin B12), macronutrients, and phytonutrients including, ginger compounds, and quercetin. Ten adults with Crohn’s disease or ulcerative colitis were recruited from the Portland metropolitan area. Participants consumed a beverage twice daily for 12 weeks. 

The researchers wanted to see if the beverage affected blood nutrients and blood cells involved in immunity. Primary measures were the following parameters: folate, vitamin B12, red blood cell (RBC) count, haemoglobin, haematocrit, electrolytes, and albumin. Exploratory measures included a food frequency questionnaire, circulating blood cell counts, and inflammatory markers.

Nine participants completed the study and one withdrew. Adherence was 98%. Serum folate and red cell distribution width improved in adults with IBD after 12 weeks. Modulation of leukocyte subtypes was also observed, including a decrease in neutrophils and an increase in lymphocytes, with no change in total WBC count. 

The team have planned a bigger study to fully examine the effects of the beverage in IBD patients, exciting news for those who suffer from these conditions.

* GB ARTICLE 13.1 BOTANICALS ON HOLD LIST.

Photo by zhenzhong liu on Unsplash

Irritable bowel syndrome (IBS) remains a common and difficult to manage gastrointestinal condition. There is growing interest in the use of traditional medicine to manage IBS, as prescribed drugs often fail after time and revolve around symptom management of cramps and diarrhoea rather than addressing the cause of the problem. In particular, curcumin, a biologically active phytochemical, has demonstrated anti-inflammatory and antioxidant properties in several studies. 

Last year a group of researchers looked at all the studies available with IBS and curcumin. 3 studies were included in the final analysis this included treatment of 326 patients.

They found curcumin to have a beneficial effect on IBS symptoms. With its unique antioxidant and anti-inflammatory activities, and ability to modulate gut microbiota, curcumin is a potentially useful agent for IBS. It also appears safe and well-tolerated, with no adverse events reported in the available trials. 

There are more studies on the way looking at even more benefits that it may have in the gut and elsewhere in the body, so watch this space!

Altruvita’s Happy Tum supplement contains highly absorbable curcumin, green tea and vitamin D. Take a closer look at Happy Tum here.

Fecal Microbiota transplant (FMT) is making the news this week. It is where faeces are transplanted from a healthy person [1] into another bowel to help change the bacterial make-up; the microbiota. Yes, you read this correctly!

Why would you want to do this? It acts in the same way as a probiotic and although it sounds disgusting, it has been used very successfully in treating clostridium difficile (C. diff) infection. It also looks to be one way of treating inflammatory bowel diseases; Crohn’s disease and ulcerative colitis, since the causes of these may be from bacterial imbalance.

You may be wondering how the new microbiota get there? It is performed using nasogastric tubes, endoscopy, enema or colonoscopy. There are also ongoing trials on using carefully sealed capsules for oral administration. If the disease is in the small intestine, access through the mouth is favoured and if in the large bowel, access through the rectum is preferred.

There are some websites that show how you can try it yourself, although this could be very risky business. Faeces should be pre-screened for infectious diseases, or there is a risk of picking up more than you bargained for.

An excellent review published a few years ago, explaining the topic in more depth [2].

Have you tried diet and supplements first?

References

[1] Bakken J S et al (2011) “Treating Clostridium difficile Infection With Fecal Microbiota Transplantation”. Clinical Gastroenterology and Hepatology; 9(12):1044–1049.

[2] Kelly CR, Kahn S, Kashyap P, et al. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology. 2015;149(1):223–237. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755303/

Photo by Gesina Kunkel on Unsplash

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