Xanthohumol and ageing

Xanthohumol and ageing

Aging is associated with a deregulation of biological systems that lead to an increase in oxidative stress, among other effects. Xanthohumol is the main preylated chalcone present in hops, whose antioxidative properties, amongst others, have been shown in recent years.

In the most recent study published in the European Journal of Nutrition, the possible protective effects of xanthohumol on liver alterations associated with aging were evaluated. Half the artificially aged mice were treated with 5mg/kg/d of xanthohumol. A significant increase in protein levels of oxidative stress and proliferative markers were shown in old non-treated mice. The mice treated with xanthohumol did not have these changes associated with liver ageing. An earlier study published in the Journal of Cosmetic Science investigated xanthohumol as a skin anti-aging agent via its beneficial regulation of matrix surrounding skin cells. When Xanthohumol was applied to skin cells, it showed potential to improve skin structure and firmness: it simultaneously inhibits the activities of elastase- the enzyme that breaks down the elasticity of skin, and stimulates the biosynthesis of fibrillar collagens, elastin, and fibrillins.

Other studies such as that published in the Journal of Nutritional Biochemistry are now showing that xanthohumol treatment modulated the biological processes, exerting a protective effect on brain damage induced by aging.

The antioxidative properties of xanthohumol strengthen body cells in fighting oxidation induced aging*.

* EU Registers on nutrition and health claims and EFSA Article 13.1 botanicals on hold list.

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