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Xanthohumol now used in IBD research

Crohn’s disease and Ulcerative Colitis are the two most common forms of Inflammatory Bowel Disease (IBD), and together they affect more than 300,000 people in the UK. IBDs can trigger a wide range of symptoms including pain, cramps, weight loss, extreme tiredness, diarrhoea and swelling of the stomach. 

Due to the high prevalence of nutrient deficiencies in patients with IBD, routine monitoring of nutrient status and supplementation are recommended. Not only are deficiencies a wider problem, but the resulting inflammation causes pain and intolerance to food during flare ups when the diseases are active.

Xanthohumol is an extract of the hop flower which protects body cells from the damage caused by free radicals. Xanthohumol protects body cells from oxidation-induced cell stress and reinforces cell protection*

A team in Portland, Oregon, who have been running multiple studies investigating the health benefits of xanthohumol hop extracts, have released their latest preliminary study, this time in IBD. The formula contained xanthohumol and curcumin, which is well studied for its anti-inflammatory effects* in IBD. The formula also contained a mixture of micronutrients (including methylated forms of folate and vitamin B12), macronutrients, and phytonutrients including, ginger compounds, and quercetin. Ten adults with Crohn’s disease or ulcerative colitis were recruited from the Portland metropolitan area. Participants consumed a beverage twice daily for 12 weeks. 

The researchers wanted to see if the beverage affected blood nutrients and blood cells involved in immunity. Primary measures were the following parameters: folate, vitamin B12, red blood cell (RBC) count, haemoglobin, haematocrit, electrolytes, and albumin. Exploratory measures included a food frequency questionnaire, circulating blood cell counts, and inflammatory markers.

Nine participants completed the study and one withdrew. Adherence was 98%. Serum folate and red cell distribution width improved in adults with IBD after 12 weeks. Modulation of leukocyte subtypes was also observed, including a decrease in neutrophils and an increase in lymphocytes, with no change in total WBC count. 

The team have planned a bigger study to fully examine the effects of the beverage in IBD patients, exciting news for those who suffer from these conditions.

* EU EFSA ARTICLE 13.1 BOTANICALS ON HOLD LIST.

Photo by zhenzhong liu on Unsplash